Does tirzepatide affect your period?

Yes, tirzepatide (the active ingredient in Zepbound) can absolutely affect your menstrual cycle. Since tirzepatide helps regulate blood sugar and promotes weight loss by targeting GLP-1 and GIP receptors, it also influences hormone production and fat metabolism. This means Zepbound and period changes —like missed periods, irregular bleeding, or heavier flow—are not uncommon. As fat cells shrink, stored estrogen is released, sometimes triggering temporary hormonal imbalances.

Can semaglutide mess with your menstrual cycle?

Semaglutide, another GLP-1 medication similar to tirzepatide, has also been linked to cycle disruptions. Like Zepbound, it can delay ovulation, shorten cycles, or stop periods entirely in some users. If you’re transitioning between GLP-1s or switching from Zepbound to another med like Wegovy, these shifts might explain your symptoms. You can read more about transitions in this guide .

Can Wellbutrin affect your period?

Yes. Wellbutrin (bupropion) is known to affect hormone signaling through the hypothalamus-pituitary-ovarian axis. In combination with Zepbound and period shifts already occurring from weight loss, Wellbutrin may amplify symptoms like irregular bleeding, early periods, or longer luteal phases. If you're on both medications, tracking symptoms daily is key.

Does selenium affect the menstrual cycle?

Selenium is a trace mineral that plays a role in thyroid health. And since the thyroid heavily influences your menstrual cycle, selenium deficiency—or excess—can cause missed periods, ovulatory delay, or shorter cycles. If you’re taking Zepbound and also supplementing with selenium, be mindful of your thyroid markers and menstrual timing.

Can azithromycin affect your period?

Azithromycin is an antibiotic and doesn't typically alter hormones, but it may temporarily affect your period through stress on the immune system or by disrupting gut bacteria that play a role in estrogen metabolism. Combine this with Zepbound and period imbalances already in play, and it could contribute to unusual spotting or cramping.

Zepbound And Period Changes – 5 Truths Women Should Know Now

Name: Zepbound Hormone-Balancing Bowl
Prep time: 10 min
Cook time: 25 min
Total time: 35 min
Cuisine: Healthy
Ingredients: 1 cup cooked lentils (green or brown); 1 medium sweet potato, cubed; 1 avocado, sliced; 2 cups mixed greens (spinach, kale, arugula); ¼ cup shredded carrots; 2 tablespoons pumpkin seeds; 2 tablespoons chopped parsley; Olive oil, salt, pepper; 3 tablespoons tahini; Juice of 1 lemon; ½ teaspoon turmeric; 1 teaspoon maple syrup; 2 tablespoons warm water; Pinch of sea salt

Description

A hormone-balancing bowl rich in fiber, healthy fats, and plant-based protein. Perfect for a nourishing lunch or dinner.

Ingredients

Scale

1 cup cooked lentils (green or brown)
1 medium sweet potato, cubed
1 avocado, sliced
2 cups mixed greens (spinach, kale, arugula)
¼ cup shredded carrots
2 tablespoons pumpkin seeds
2 tablespoons chopped parsley
Olive oil, salt, pepper

Lemon-Turmeric Tahini Dressing:

3 tablespoons tahini
Juice of 1 lemon
½ teaspoon turmeric
1 teaspoon maple syrup
2 tablespoons warm water
Pinch of sea salt

Instructions

Roast the sweet potato. Toss cubes in olive oil, salt, and pepper. Roast at 400°F (200°C) for 25 minutes until tender and golden.
Cook lentils if not already prepared. Season with a pinch of sea salt.
Make the dressing by whisking tahini, lemon juice, turmeric, maple syrup, warm water, and sea salt until smooth.
Assemble bowls: greens first, followed by lentils, sweet potato, avocado, carrots, and parsley.
Drizzle with the dressing. Sprinkle with pumpkin seeds. Serve warm or chilled.

Prep Time: 10 minutes
Cook Time: 25 minutes
Category: Lunch
Method: Roasting
Cuisine: Healthy

Nutrition

Serving Size: 1 bowl
Calories: 350
Sugar: 5g
Sodium: 220mg
Fat: 20g
Saturated Fat: 3g
Unsaturated Fat: 15g
Trans Fat: 0g
Carbohydrates: 32g
Fiber: 9g
Protein: 10g
Cholesterol: 0mg

Keywords: hormone-balancing, healthy bowl, vegan, gluten-free, lentils, tahini dressing